Oxidative Stress of Cyclosporine on Kidney Functions and Antioxidant Role of Cinnamon

Abstract

In this study, the oxidative effect of cyclosporine A (Cyc A) with or without cinnamon extract on kidney functions and some antioxidant enzymes in male rabbits was investigated. Levels of Na and K were depressed significantly after treatment with cyclosporine A compared to the control. A significant increase was found for Ca levels during treatment with cyclosporine A. Levels of TBARS showed a significant increase after treatment with cyclosporine A compared to the control. Levels of GSH and GST were significantly lower after treatment with cyclosporine A. Levels of these parameters were affected by the effect of cinnamon extract. It is well known that glutathione-S-transferase (GST) and glutathione play an important role in the detoxification of toxic metabolites, where GSH is catalysed by GST. One of the hypotheses explaining the detoxifying function of GST is the binding between GSH and endogenous or exogenous toxic substances; it plays an important role in the storage and excretion of xenobiotic compounds