The Relationship Between Renal Stones and Parathyroid Hormone

Abstract

This study aimed to evaluate the relationship between biologic markers and parathyroid hormone (PTH) in stone patients. Two hundred patients (one hundred renal stones and one hundred healthy controls) formed this hospital-based case-control study. Tests for serum levels of PTH, calcium, phosphorus, and creatinine were performed and analyzed statistically. Phosphorus concentrations were significantly reduced while PTH and calcium concentrations were significantly increased in renal stone patients versus controls (p < 0.001). Creatinine levels showed no obvious differences. PTH had a moderately positive correlation with creatinine (r = 0.35), a negative correlation with phosphorus (r = -0.48), and a strong, positive correlation with calcium (r = 0.62). PTH excess stimulates renal stone formation by deranging calcium and phosphate metabolism. Conclusion: Regular PTH measurements could improve the diagnosis and management of nephrolithiasis